Thermo Fisher Scientific KCNA2 Polyclonal Antibody
KCNA2 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC에 적합합니다. 사람, 생쥐, 랫트 시료에 반응하며, 합성 펩타이드를 면역원으로 사용했습니다. 동결건조 형태로 제공되며 연구용으로만 사용 가능합니다.
- 카탈로그번호
- OSK00002W-100UL
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of rat KCNA2 (Potassium voltage gated channel subfamily A member 2, Kv1.2) conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: KCNA2.
Target Information
Kcna2 is a voltage-gated potassium channel (KV) belonging to the 6-TM family of potassium channels, which also includes the Ca²⁺-activated Slo (7-TM) and SK subfamilies. The α-subunits form tetramers with a single pore-forming region. Potassium channels regulate neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four related potassium channel genes—shaker, shaw, shab, shal—have been identified in Drosophila, each with human homologs.
The Kcna2 gene encodes a voltage-gated, shaker-related potassium channel with six transmembrane domains and a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, aiding efficient nerve cell repolarization after an action potential.
The coding region is intronless and clustered with KCNA3 and KCNA10 on chromosome 1.
Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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