Thermo Fisher Scientific Protein C Monoclonal Antibody (CaC-11)
인간 Protein C를 인식하는 Mouse IgG1 단클론 항체로 ELISA와 Western Blot에 사용 가능. 비결합형 액상 형태이며 Protein G로 정제됨. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
- 카탈로그번호
- MA517645
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CaC-11 |
| Immunogen | Human Protein C purified from the supernatant of thrombin activated platelets |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539035 |
Product Specific Information
MA5-17645 targets Protein C/APC in ELISA and WB applications and shows reactivity with Human samples.
The immunogen used is human Protein C purified from the supernatant of thrombin activated platelets.
Target Information
Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. The activated form contains a serine protease domain and functions in degradation of activated coagulation factors V and VIII.
Protein C is produced in the liver and composed of two polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to endothelial receptors, forming a 55 kDa active enzyme that cleaves factor Va and VIIIa, inhibiting coagulation.
Normal human plasma concentrations are approximately 1–3 ng/mL for the active enzyme and 3 µg/mL for the proenzyme.
Mutations in the Protein C gene are associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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