Thermo Fisher Scientific IRE1 alpha Polyclonal Antibody
Thermo Fisher Scientific의 IRE1 alpha Polyclonal Antibody는 인간 IRE1α 단백질(Residues 200–300)에 특이적으로 반응하는 Rabbit Polyclonal 항체입니다. Western blot 검증 완료, 0.9 mg/mL 농도의 액상 형태로 제공되며, ER 스트레스 신호 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 200–300 of human IRE1 alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2262265 |
Target Information
ERN1 serine/threonine kinase, also known as endoplasmic reticulum to nucleus signaling 1 (IRE1), is a human homologue of the yeast Ire1 gene product. It possesses intrinsic kinase and endoribonuclease activities that play a critical role in endoplasmic reticulum (ER)-based stress signaling.
ERN1 regulates IRE1 proteolysis in mammalian cells and is essential for fetal viability through its function in extraembryonic cells.
IRE1 acts as a sensor of unfolded proteins in the ER, initiating the unfolded protein response (UPR) by splicing XBP1 mRNA into a potent transcriptional activator. While null mutants are viable under normal conditions, IRE1 is essential under stress conditions that lead to unfolded protein accumulation in the ER.
Depletion of IRE1p or expression of a dominant negative form has minimal effect under normal conditions but induces apoptosis under ER stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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