Thermo Fisher Scientific CD34 Monoclonal Antibody (4H11[APG]), Alexa Fluor 488

Applications

Western Blot (WB)

• Assay-dependent

Immunocytochemistry (ICC/IF)

• Assay-dependent

Flow Cytometry (Flow)

• 4 µL/100 µL whole blood or 10^6 cells

Product Specifications

Additional Formats

• Unconjugated (MA1-19229)
• APC (MA1-19466)
• Biotin (MA1-19515)
• FITC (MA1-19593)
• PE (MA1-19645)
• Request custom conjugation available

Product Specific Information

This antibody reacts with extracellular class III epitope on CD34, a 110–115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitor cells and pluripotential stem cells. The antibody 4H11[APG] completely blocks binding of class III antibodies BIRMA K3 and 8G12 on KG1a cell line.

Target Information

CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) present on various stem cell populations. It serves as a stem cell marker and may function as a receptor involved in adhesion, differentiation, and proliferation of hematopoietic progenitors. CD34 expression indicates a specific developmental state and may facilitate cell-matrix interactions in bone marrow. It also acts as a scaffold for glycans, enabling binding to lectins and selectins. The intracellular domain is phosphorylated by protein kinase C, suggesting a role in signal transduction. CD34 dysfunction is associated with dermatofibrosarcoma and neurofibroma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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