Thermo Fisher Scientific CD41 Monoclonal Antibody (MEM-06), Alexa Fluor 488
인간 CD41(GPIIb)을 인식하는 마우스 단클론 항체로, Alexa Fluor 488 형광으로 표지되어 있습니다. 혈소판 및 거대핵세포 표면 분석에 적합하며, 유세포분석(Flow Cytometry)에 사용됩니다. 4°C 암소 보관, 동결 금지.
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Applications
- Flow Cytometry (Flow): 4 µL/100 µL of whole blood or 10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-06 |
| Immunogen | Leukocytes of patient suffering from LGL-type leukaemia |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539511 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- Biotin
- FITC
- PE
- PerCP
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein of the integrin family composed of two chains: GPIIb alpha (120 kDa) and GPIIb beta (23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Target Information
CD41 (platelet glycoprotein IIb, ITGA2B) consists of two subunits (120 kDa alpha and 23 kDa beta) that form a functional adhesive protein receptor with CD61 in the presence of calcium. CD41 mediates platelet aggregation and binds to proteins such as von Willebrand factor, fibrinogen, fibronectin, and vitronectin upon vascular injury. It is primarily expressed in the megakaryocyte-platelet lineage and during early hematopoietic differentiation.
Diseases associated with CD41 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 bleeding disorder.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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