Thermo Fisher Scientific IL6 Monoclonal Antibody (OTI2G3), TrueMAB
인간 IL-6에 특이적인 마우스 단클론 항체로, Western blot에 적합합니다. 무보존제 동결건조 형태이며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 염증 및 면역 반응 연구용으로 최적화된 TrueMAB 제품입니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G3 |
| Immunogen | Recombinant protein expressed in E. coli corresponding to amino acids 29–212 of human IL-6 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
IL-6 encodes a cytokine involved in inflammation and B cell maturation. The protein acts as an endogenous pyrogen, inducing fever in autoimmune or infectious diseases.
It is primarily expressed at sites of acute and chronic inflammation, secreted into serum, and activates transcriptional inflammatory responses via the interleukin 6 receptor alpha.
IL-6 is implicated in multiple inflammation-associated diseases, including diabetes mellitus susceptibility, systemic juvenile rheumatoid arthritis, Kaposi sarcoma, and rheumatoid arthritis. Elevated IL-6 levels have been observed in viral infections such as COVID-19 (SARS-CoV-2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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