Thermo Fisher Scientific IL-10 Monoclonal Antibody (JES3-9D7), PE, eBioscience

Thermo Fisher Scientific IL-10 Monoclonal Antibody (JES3-9D7), PE, eBioscience

Applications

• Flow Cytometry (Intracellular staining)

Tested Dilution

• 5 µL (0.125 µg)/test

Publications

• View 17 publications

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 488
• Brilliant UV 395
• Brilliant UV 737
• Brilliant Violet 421
• Brilliant Violet 480
• Brilliant Violet 711
• eFluor 450
• eFluor 660
• Functional Grade
• PE-Cyanine7
• PerCP-eFluor 710
• Request custom conjugation

Product Specific Information

The JES3-9D7 monoclonal antibody reacts with human interleukin-10 (IL-10).
Applications Reported: JES3-9D7 has been reported for use in intracellular staining and flow cytometric analysis.
Applications Tested: Pre-titrated and tested by intracellular staining and flow cytometric analysis of human activated cells. Recommended use: 5 µL (0.125 µg) per test (100 µL final volume). Cell number range: 10⁵–10⁸ cells/test.
Excitation: 488–561 nm; Emission: 578 nm; Laser: Blue, Green, Yellow-Green.
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

IL-10 encodes a cytokine primarily produced by monocytes and lymphocytes. It regulates immune responses and inflammation by down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. IL-10 enhances B cell survival, proliferation, and antibody production, blocks NF-kappa B activity, and regulates the JAK-STAT signaling pathway.
Knockout studies indicate IL-10 is essential for intestinal immune regulation. Mutations are associated with susceptibility to HIV-1 infection and rheumatoid arthritis.
Diseases associated with IL10 include Graft-Versus-Host Disease and HIV Type 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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