Thermo Fisher Scientific CD11c Monoclonal Antibody (N418), Alexa Fluor 660, eBioscience

Applications and Tested Dilution

• Application: Flow Cytometry (Flow)
• Tested Dilution: 0.5 µg/test

Product Specifications

Additional Formats Available

• Unconjugated
• Alexa Fluor 488, 532, 700
• APC, APC-eFluor 780
• Biotin, Brilliant UV/BV 시리즈
• eFluor 450, 506, 615, 660
• FITC, PE, PE-Cyanine5/5.5/7, PE-eFluor 610
• PerCP-Cyanine5.5, Super Bright 시리즈
• NovaFluor Blue/Yellow 시리즈
• Request custom conjugation

Product Specific Information

The N418 monoclonal antibody reacts with mouse CD11c (integrin alpha X), which associates with beta2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, subsets of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. It binds to CD54, iC3b, and fibrinogen, playing a role in leukocyte adhesion.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Tested on mouse splenocytes (≤0.5 µg/test)
  • Defined as the amount that stains a cell sample in 100 µL
  • Recommended to titrate for optimal performance
• Fluorophore Info: Alexa Fluor 660 emits at 690 nm
  • Suitable for spectral cytometers
  • Multiplexing possible with APC, Alexa Fluor 647, and Alexa Fluor 700
  • Excitation: 662 nm / Emission: 690 nm / Laser: Red Laser

Target Information

CD11, with CD18, forms a heterodimer adhesion molecule.

• CD11a: Expressed in B, T lymphocytes, macrophages, monocytes, neutrophils, basophils, eosinophils
• CD11b: Found in monocytes, macrophages, NK cells, some B/T cells, granulocytes
• CD11c: Expressed in monocytes, macrophages, NK cells, some granulocytes, and subsets of lymphocytes

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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