Thermo Fisher Scientific SIP1 Polyclonal Antibody
Thermo Fisher Scientific의 SIP1 Polyclonal Antibody는 ZEB2(Smad interacting-protein 1)를 인식하는 rabbit polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 적합합니다. FFPE 조직에서는 citrate buffer(pH 6.0)로 epitope retrieval을 권장하며, 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1164 and 1214 of Human Smad interacting-protein 1 (ZEB2, UniProt ID: O60315-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
ZEB2, also known as Smad interacting-protein 1, is a nuclear DNA-binding transcriptional repressor that interacts with activated SMADs. Similar to ZEB1, ZEB2 inhibits E-cadherin transcription and induces epithelial-mesenchymal transition (EMT), regulating cell migration during development and wound healing. ZEB2 may protect cells from DNA damage-induced apoptosis, contributing to tumor progression. It is often observed in the cytoplasm of cancer tissues, suggesting localization regulation. Mutations in ZEB2 are associated with Hirschsprung disease and Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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