Thermo Fisher Scientific SHANK3 Polyclonal Antibody
SHANK3 단백질을 검출하기 위한 Thermo Fisher Scientific의 폴리클로날 항체입니다. WB 및 IHC에 사용 가능하며, 인간과 마우스 시료에 반응합니다. 액상 형태로 제공되며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid synthetic peptide near the center of human SHANK3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551735 |
Product Specific Information
A suggested positive control is NIH-3T3 cell lysate.
PA5-34383 can be used with blocking peptide PEP-1426.
Target Information
SHANK3 is a major scaffold postsynaptic density protein that interacts with multiple proteins and complexes to orchestrate dendritic spine and synapse formation, maturation, and maintenance.
It interconnects receptors of the postsynaptic membrane, including NMDA-type and metabotropic glutamate receptors, via complexes with GKAP/PSD-95 and HOMER, and the actin-based cytoskeleton.
SHANK3 plays a role in structural and functional organization of dendritic spine and synaptic junction through interactions with Arp2/3 and WAVE1 complex, promoting F-actin clusters.
By controlling actin dynamics, SHANK3 regulates developing neurons’ growth cone motility and NMDA receptor signaling.
It modulates GRIA1 exocytosis and GRM5/MGLUR5 expression to control AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity.
SHANK3 may be required at an early stage of synapse formation and can be inhibited by IGF1 to promote synapse maturation. (Uniprot)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
배송 정보
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