Thermo Fisher Scientific Phospho-EP3 Prostanoid Receptor (Thr372, Ser373) Polyclonal Antibody

Thermo Fisher Scientific Phospho-EP3 Prostanoid Receptor (Thr372, Ser373) Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:1,000
Publications: - [References not provided]

Product Specifications

Target Information

CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells, and hematopoietic stem cells.
CD172a acts as a substrate for activated tyrosine kinases such as EGFR, PDGFR, Src, and insulin receptor, and plays a role in the negative regulation of receptor tyrosine kinase-coupled signaling pathways.
Ligand binding of CD172a to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of ITIM motifs within its cytoplasmic region, recruiting SHP-1 and SHP-2 phosphatases that regulate cellular functions via substrate dephosphorylation.
Interaction between CD172a and CD47 is involved in several regulatory processes, including inhibition of macrophage phagocytosis and bi-directional activation of T cells and dendritic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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