Thermo Fisher Scientific Phospho-EP3 Prostanoid Receptor (Thr372, Ser373) Polyclonal Antibody
인산화된 EP3 프로스타노이드 수용체(Thr372, Ser373)를 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도, PBS buffer에 sodium azide 포함. 연구용으로만 사용 가능.
- 카탈로그번호
- 7TM0342B
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-EP3 Prostanoid Receptor (Thr372, Ser373) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human EP around the phosphorylation site of Thr372/Ser373 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco's PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells, and hematopoietic stem cells.
CD172a acts as a substrate for activated tyrosine kinases such as EGFR, PDGFR, Src, and insulin receptor, and plays a role in the negative regulation of receptor tyrosine kinase-coupled signaling pathways.
Ligand binding of CD172a to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of ITIM motifs within its cytoplasmic region, recruiting SHP-1 and SHP-2 phosphatases that regulate cellular functions via substrate dephosphorylation.
Interaction between CD172a and CD47 is involved in several regulatory processes, including inhibition of macrophage phagocytosis and bi-directional activation of T cells and dendritic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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