Thermo Fisher Scientific AKT Monoclonal Antibody
AKT 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, IHC, ELISA, IP 등 다양한 응용에 적합합니다. 인간, 생쥐, 랫드, 침팬지에 반응하며, 액상 형태로 제공되어 안정적인 보관 및 재현성 높은 결과를 제공합니다.
- 카탈로그번호
- 200-301-B26
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (IHC) | 20 µg/mL |
| ELISA | 1:20,000 |
| Immunoprecipitation (IP) | 1:500–1:3,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chimpanzee, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | Anti-Akt monoclonal antibody produced by repeated immunizations with a synthetic peptide corresponding to residues near the C-terminal end of human AKT1 protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This antibody is specific for human and mouse AKT protein.
A BLAST analysis suggests cross-reactivity with AKT from human, mouse, rat, and chimpanzee sources based on 100% homology with the immunizing sequence.
Cross-reactivity with AKT2 and AKT3 has not been determined.
Target Information
AKT, also known as protein kinase B (PKB) or RAS-alpha, is a ubiquitous serine/threonine kinase involved in regulating metabolism, cell survival, and growth by phosphorylating multiple proteins.
It is activated by insulin, PI3K, IGF1, and various other growth and survival factors.
Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors and caspase-9.
The AKT pathway is a major target for cancer drug discovery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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