Thermo Fisher Scientific AKT Monoclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

This antibody is specific for human and mouse AKT protein.
A BLAST analysis suggests cross-reactivity with AKT from human, mouse, rat, and chimpanzee sources based on 100% homology with the immunizing sequence.
Cross-reactivity with AKT2 and AKT3 has not been determined.

Target Information

AKT, also known as protein kinase B (PKB) or RAS-alpha, is a ubiquitous serine/threonine kinase involved in regulating metabolism, cell survival, and growth by phosphorylating multiple proteins.
It is activated by insulin, PI3K, IGF1, and various other growth and survival factors.
Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors and caspase-9.
The AKT pathway is a major target for cancer drug discovery.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.