Thermo Fisher Scientific ATG12 Recombinant Rabbit Monoclonal Antibody (9R8W2)
ATG12 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단일클론 항체로, Western blot 및 ELISA에 적합합니다. HEK293 세포에서 발현되었으며, 높은 순도와 안정성을 제공하며 인체, 마우스, 랫트 시료에 반응합니다. 세포 내 자가포식 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9R8W2 |
| Immunogen | Synthetic peptide corresponding to amino acids 41–140 of human Apg12 (O94817) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.85 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911855 |
Product Specific Information
Positive test controls include PC-3, Mouse brain, and Mouse stomach.
The target is typically localized in the cytoplasm, peripheral membrane protein, and preautophagosomal structure membrane.
Immunogen sequence:
SPGTEEPAGD TKKKIDILLK AVGDTPIMKT KKWAVERTRT IQGLIDFIKK FLKLVASEQL FIYVNQSFAP SPDQEVGTLY ECFGSDGKLV LHYCKSQAWG
Target Information
ATG12 is a member of the autophagy protein family that forms a conjugate with ATG5, exhibiting ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy.
This conjugate interacts with innate immune response proteins such as RIG-I and VISA (IPS-1), inhibiting type I interferon production and facilitating viral replication.
ATG12 also interacts with ATG10 in human embryonic kidney cells in the presence of ATG7.
At least two isoforms of ATG12 are known.
Autophagy, the process of bulk degradation of cellular proteins through the autophagosomal-lysosomal pathway, is vital for normal growth control and nutrient preservation under starvation.
This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(MA5-42714_ATG12_O94817-1_Rabbit_PDP.jpeg)
(MA5-42714_ATG12_O94817-1_Rabbit.svg)
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