Thermo Fisher Scientific IL-1 beta Recombinant Rabbit Monoclonal Antibody (7E1S4)
IL-1 beta를 인식하는 토끼 단클론 항체로, Western blot, ICC/IF, ELISA에 적합합니다. HEK293 발현 시스템에서 생산된 재조합 항체이며, 인간 및 마우스 시료에 반응합니다. 친화 크로마토그래피로 정제되어 고순도이며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7E1S4 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 117–269 of human IL1β (NP_000567.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2911860 |
Product Specific Information
- Positive test control: THP-1
- Subcellular localization: Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted, Autophagosome, Cytosol, Exosome
- Immunogen sequence:
APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into an active 17 kDa form via inflammasome activation. IL-1β signals through IL-1RI and IL-1RII receptors and plays a key role in innate immune responses by inducing other proinflammatory cytokines. Elevated IL-1β levels are associated with chronic inflammatory conditions, and neutralizing antibodies targeting IL-1β have potential therapeutic applications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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