Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), eFluor 450, eBioscience
마우스 CD41을 인식하는 eBioMWReg30 단클론 항체로, eFluor 450 형광체가 결합되어 있습니다. 혈소판 및 조혈 줄기세포 연구용으로 적합하며, 유세포분석(Flow Cytometry)에 최적화되어 있습니다. 405/445 nm에서 여기/방출되며, 4°C 암소 보관이 권장됩니다.
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- 48-0411-8x (2개 옵션)
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), eFluor 450, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 5 publications |
| Immunocytochemistry (ICC/IF) | - | View 8 publications |
| Flow Cytometry (Flow) | 0.5 µg/test | View 42 publications |
| Immunoprecipitation (IP) | - | View 1 publication |
| Functional Assay | - | View 2 publications |
| Peptide Array | - | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Published Species | Hamster, Human, Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), eFluor™ 450, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioMWReg30 (MWReg30) |
| Conjugate | eFluor™ 450 |
| Excitation / Emission Max | 405 / 445 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
| RRID | AB_1582239 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- FITC
- Functional Grade
- NovaFluor Blue 510
- NovaFluor Blue 555
- NovaFluor Blue 660-120S
- NovaFluor Yellow 570
- NovaFluor Yellow 660
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). CD41 is expressed on platelets, megakaryocytes, and hematopoietic progenitors in the embryo, fetus, and adult. It associates with CD61 (gpIIIa, integrin beta III) to form a receptor essential for platelet function, including binding of adhesion molecules such as fibrinogen, fibronectin, and vitronectin.
The SLAM-family markers CD48 and CD150 are used to identify hematopoietic stem cells (HSC). CD150⁺CD48⁻ bone marrow cells show high efficiency in long-term multi-lineage reconstitution, which is enhanced when CD41⁺ cells are excluded. Thus, CD150⁺CD48⁻CD41⁻ expression efficiently identifies HSCs.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested by flow cytometry of mouse platelets at ≤0.5 µg/test (100 µL final volume). Cell number should be empirically determined (10⁵–10⁸ cells/test). Antibody titration is recommended for optimal results.
Fluorophore Information:
eFluor® 450 is an alternative to Pacific Blue®. It emits at 445 nm and is excited with the Violet laser (405 nm). Ensure instrument compatibility.
- Excitation: 405 nm
- Emission: 445 nm
- Laser: Violet
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD41 (platelet glycoprotein IIb, ITGA2B) consists of two subunits (120 kDa α and 23 kDa β) that interact with CD61 in the presence of calcium to form a functional adhesive receptor. CD41 mediates platelet aggregation and binds to von Willebrand factor, fibrinogen, fibronectin, and vitronectin upon vascular injury. It is mainly expressed in the megakaryocyte-platelet lineage and during early hematopoietic differentiation.
Associated Diseases: Glanzmann Thrombasthenia, Platelet-type 16 bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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