Thermo Fisher Scientific Syntaphilin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Despite its predicted molecular weight, Syntaphilin often migrates at a higher molecular weight in SDS-PAGE.
A suggested positive control is human brain tissue lysate.
PA5-20528 can be used with blocking peptide PEP-0648.

Target Information

Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25.
Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis.
Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis.
Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function.
Multiple isoforms are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.