Thermo Fisher Scientific Syntaphilin Polyclonal Antibody
Syntaphilin 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 제품으로, 단기 냉장 보관 및 장기 냉동 보관 권장. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | – |
| Immunohistochemistry (IHC) | 5 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the center of human Syntaphilin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C up to 3 months; long-term at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155821 |
Product Specific Information
Despite its predicted molecular weight, Syntaphilin often migrates at a higher molecular weight in SDS-PAGE.
A suggested positive control is rat brain tissue lysate.
PA5-20529 can be used with blocking peptide PEP-0649.
Target Information
Syntaphilin was initially identified in a yeast two-hybrid screen using the carboxy terminal region of Syntaxin-1 as bait.
Syntaxin-1 is a key component of the synaptic vesicle docking machinery forming the SNARE complex with synaptobrevin and SNAP-25.
Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation, thereby regulating synaptic vesicle exocytosis.
It also binds dynamin-1 and inhibits dynamin-dependent endocytosis.
Mice lacking syntaphilin show increased mitochondrial motility and reduced axonal mitochondrial density, correlating with enhanced short-term facilitation and motor impairments, suggesting a major role in presynaptic function.
Multiple isoforms are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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