Thermo Fisher Scientific B-Raf Polyclonal Antibody
B-Raf 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간·마우스·랫트 반응성. Western blot, IHC, IP에 사용 가능. 항원 친화 크로마토그래피로 정제된 고순도 제품. 장기 보관 시 -20°C에서 안정적.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human B-Raf |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.21 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792262 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: A549, H1299, HCT116, PC-12.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer and is thought to play a role in the postsynaptic responses of hippocampal neurons. This protein regulates the MAP kinase/ERK signaling pathway, affecting cell division, differentiation, and secretion. Mutations in B-Raf have been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and lung adenocarcinoma. A pseudogene located on chromosome X has also been identified for B-Raf.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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