Thermo Fisher Scientific JNK1 Monoclonal Antibody (OTI2C6), TrueMAB
인간 JNK1 단백질을 인식하는 마우스 단클론 항체로 Western Blot 및 IHC(P) 실험에 적합합니다. 무보존제, 동결건조 형태이며 재구성 후 1 mg/mL 농도로 사용 가능합니다. MAPK 신호전달 연구 및 스트레스 반응 경로 분석에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–384 of human JNK1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum and plays a key role in insulin resistance and obesity.
It belongs to the MAPK superfamily of stress-activated protein kinases, which mediate signal transduction from the cell surface to the nucleus.
JNK is involved in cellular processes such as proliferation, differentiation, transcription regulation, and development.
JNK pathways are activated by stress and inflammatory signals and expressed as ten different isoforms due to differential mRNA splicing, with JNK1 and JNK2 being predominant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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