Thermo Fisher Scientific ST2 Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 Rabbit Polyclonal ST2 항체. Western blot에 적합하며, IL-33 수용체 연구용으로 사용. Protein G로 정제된 0.5 mg/mL 액상 제품으로, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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- PA523206
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Applications
- Western Blot (WB): 3–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 207–238 of human ST2V |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540732 |
Target Information
IL-33R, also known as ST2, is a receptor for IL-33 and a member of the IL-1 receptor family. Its extracellular domain contains three Ig-like domains that interact with co-receptor IL-1RAcP and ligand IL-33. Binding of IL-33 induces complex formation with adaptor proteins (MyD88, IRAK1, IRAK4, TRAF6), activating NF-κB and MAPK pathways, leading to cytokine release (IL-5, IL-6, IL-8, IL-13).
Two main isoforms exist due to alternative splicing: ST2L (membrane-bound) and ST2S (soluble). The soluble form may act as a decoy receptor modulating IL-33 signaling.
IL-33R is primarily expressed in mast cells, basophils, and eosinophils, and in mice, also on ILC2 and Th2 cells. IL-33R signaling is implicated in immune conditions such as allergies, arthritis, atherosclerosis, and sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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