Thermo Fisher Scientific ARHGAP20 Polyclonal Antibody
ARHGAP20 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin)에서 검증됨. Human 및 비인간 영장류 반응성. Protein G 정제, PBS/0.2% gelatin buffer에 0.05% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 5–8 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 570–620 of human ARHGAP20 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2540730 |
Target Information
ARHGAP20 is a potent GTPase-activating protein (GAP) that converts Rho-type GTPases into an inactive GDP-bound state. It contains a pleckstrin homology (PH) domain, a Ras-associating domain, a Rho-GAP domain, and two Annexin-like (ANXL) repeats.
ARHGAP20 acts as a direct downstream target of Rap1 in neurite outgrowth; its overexpression leads to Rho inactivation, promoting neurite outgrowth in a Rap1-dependent manner.
This gene functions as a tumor suppressor and is known to be inactivated by deletion in breast cancer and by chromosomal translocation in B-cell chronic lymphocytic leukemia.
Reports suggest its involvement in cytoskeletal rearrangements and cell signaling during spermatogenesis.
Expression is predominant in human brain, liver, ovary, and spinal cord, with lower expression in lymph nodes and fetal liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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