Thermo Fisher Scientific CD80 Monoclonal Antibody (MEM-233), APC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 10 µL per 100 µL whole blood or 10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 700
• FITC
• PE
• PerCP
• Custom conjugation upon request

Product Specific Information

This antibody reacts with an extracellular epitope of CD80 (B7-1), a 60 kDa single chain type I glycoprotein of the immunoglobulin superfamily, expressed on professional antigen-presenting cells such as dendritic cells, macrophages, and activated B lymphocytes.

Target Information

CD80 (B7-1) and CD86 (B7-2) are ligands of the T-cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152). Both are expressed on antigen-presenting cells and are essential for T-cell activation. CD80 is rapidly induced on activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cell lines, freshly isolated follicular lymphoma cells, T cells, and monocytes. CD80 provides regulatory signals to T lymphocytes through interactions with CD28 and CTLA4. Dysfunctions in CD80 are associated with diseases such as gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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