Thermo Fisher Scientific CD34 Monoclonal Antibody (4H11[APG]), APC

Applications

• Flow Cytometry (Flow): 10 µL per 100 µL whole blood or 10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Biotin
• FITC
• PE
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with an extracellular class III epitope on CD34, a 110–115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitor and pluripotent stem cells. Expression is gradually lost during cell differentiation. The 4H11 [APG] clone completely blocks binding of class III antibodies BIRMA K3 and 8G12 on the KG1a cell line.

Target Information

CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on various stem cell populations. It functions as a stem cell marker and may serve as a receptor mediating adhesion, differentiation, and proliferation of hematopoietic stem cells. CD34 expression represents a developmental stage with altered adhesion properties and differentiation potential. It may act as a scaffold for glycans, mediating interactions with lectins on stromal cells. The intracellular domain can be phosphorylated by protein kinase C, suggesting a role in signal transduction. CD34 dysfunction is associated with diseases such as dermatofibrosarcoma and neurofibroma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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