Thermo Fisher Scientific HLA-G Monoclonal Antibody (MEM-G/9), APC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 1–5 µg/mL
Publications: [References not provided]

Product Specifications

Available Formats

• Unconjugated
• Biotin
• FITC
• PE
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with the native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. Reactivity with HLA-G3 was also reported. It will not cross-react with mouse.

Target Information

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin).
The heavy chain is anchored in the membrane and expressed on fetal-derived placental cells.
The heavy chain is approximately 45 kDa and its gene contains 8 exons:

1. Exon 1: leader peptide
2. Exons 2–3: alpha1 and alpha2 domains (peptide binding)
3. Exon 4: alpha3 domain
4. Exon 5: transmembrane region
5. Exon 6: cytoplasmic tail

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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