Thermo Fisher Scientific UHRF2 Polyclonal Antibody
UHRF2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 고순도(>95%) 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length human UHRF2 (UniProt ID: Q96PU4-1, antigen range: 1–802, antigen length: 802) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2554063 |
Product Specific Information
This antibody detects endogenous UHRF2 protein at molecular weights of 56 and 90 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The UHRF2 gene encodes a nuclear protein involved in cell-cycle regulation. The encoded protein functions as a ubiquitin-ligase that ubiquinates PCNP (PEST-containing nuclear protein), potentially contributing to tumorigenesis.
It contains multiple functional domains including NIRF_N, PHD finger, SRA, and RING finger domains, which are essential for cell proliferation regulation and intranuclear degradation of polyglutamine aggregates.
Alternative splicing results in multiple transcript variants, some of which are non-protein coding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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