Thermo Fisher Scientific Kir2.1 (KCNJ2) Polyclonal Antibody
Kir2.1(KCNJ2) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. 고순도(>95%) 항원 친화 크로마토그래피 정제, 1 mg/mL 농도, PBS/glycerol buffer에 보관. 연구용 전용.
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Thermo Fisher Scientific Kir2.1 (KCNJ2) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 90–140 of human KIR2.1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2554069 |
Product Specific Information
- Detects endogenous Kir2.1 protein at approximately 48 kDa
- Purity >95% by SDS-PAGE
Target Information
The KIR2 subunit family includes 2.1, 2.2, 2.3, and 2.4. Unlike G protein-coupled KIR3 subunits, KIR2.1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity.
KIR2.1 is expressed in the superior and inferior colliculi and the pontine region of the brain, moderating synaptic transmission like other potassium channels.
In the placenta, KIR2.1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, it colocalizes with KIR5.1 in the proximal tubule.
KIR2.1, 2.2, and 2.3 associate with membrane-associated guanylate kinase synapse-associated protein 97 in the cerebellum and heart.
Phosphorylation of KIR2.2 by protein kinase A inhibits its association with SAP97.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(PA5-37452_Kir2.1_KCNJ2_P63252-1_Rabbit.svg 및 PA5-37452_Kir2.1_KCNJ2_P63252-1_Rabbit_PDP.jpeg)
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