Thermo Fisher Scientific GRP94 Monoclonal Antibody (9G10)
GRP94 단백질을 검출하는 Rat IgG2a 단일클론 항체로, Western blot, IHC, ICC/IF, IP 등에 사용 가능. 다양한 종(인간, 생쥐, 닭 등)에 반응하며, 액상 형태로 제공. 연구용으로만 사용.
- 카탈로그번호
- MA3016
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific GRP94 Monoclonal Antibody (9G10)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:1,000 | View 11 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | View publication |
| Immunocytochemistry (ICC/IF) | 1:250 | View 5 publications |
| Immunoprecipitation (IP) | Assay-dependent | View 4 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Chicken, Hamster, Human, Mouse, Rat |
| Published Species | Chicken, Hamster, Human, Mouse, Pig, Rat, Xenopus |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9G10 |
| Immunogen | Chick oviduct GRP94 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2248666 |
Product Specific Information
MA3-016 detects glucose regulated protein 94 kDa (GRP94) from human, rat, mouse, chick, hamster, and bovine tissues.
It is also expected to react with GRP94 from Xenopus, canine, rabbit, non-human primate, Drosophila, and ovine tissues.
This antibody has been successfully used in:
- Western blot
- Immunohistochemistry (paraffin)
- Immunocytochemistry / Immunofluorescence
- Immunoprecipitation
By Western blot, this antibody detects an approximately 108 kDa protein representing GRP94 in chick oviduct cytosol.
The immunogen is chick oviduct GRP94.
Target Information
GRP94 is an 803 amino acid protein belonging to the heat shock protein 90 family.
It functions as a molecular chaperone involved in the processing and transport of secreted proteins.
GRP94 and its N-terminal fragment stimulate CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC).
Key roles include:
- Innate and acquired immunity
- Maturation and chemotaxis of dendritic cells
- Antibody production and cross-priming
- Peptide loading of MHC class I molecules
- Potential marker in breast cancer
- Suppression of apoptosis and stabilization of calcium homeostasis
GRP94 is expressed in melanoma, liver metastases of colon carcinoma cells, and human gastric carcinoma BGC-823 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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