
Thermo Fisher Scientific CARS Monoclonal Antibody (CL2302)
Human CARS 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로 Western blot 및 IHC(Paraffin) 실험에 적합함. 단백질 A로 정제된 액상 형태이며, 1 mg/mL 농도. PBS + 40% glycerol buffer에 보관, 단기 4°C, 장기 -20°C 저장 권장.
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Applications
- Western Blot (WB): 1 µg/mL
- Immunohistochemistry (Paraffin) (IHC (P)): 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL2302 |
| Immunogen | Recombinant protein corresponding to Human CARS (UniProt ID: P49589-1, antigen range: 523–658) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2637249 |
Product Specific Information
Immunogen sequence:
SQCNLYMAAR KAVRKRPNQA LLENIALYLT HMLKIFGAVE EDSSLGFPVG GPGTSLSLEA TVMPYLQVLS EFREGVRKIA REQKVPEILQ LSDALRDNIL PELGVRFEDH EGLPTVVKLV DRNTLLKERE EKRRVEEpitope: Located within peptide sequence RPNQALLENIALYLT, determined by overlapping synthetic peptides.
Ortholog sequence identity: Mouse – 86%, Rat – 86%.
Target Information
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase (CARS). Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.
It is located near the imprinted gene domain of 11p15.5, an important tumor-suppressor region associated with various cancers and syndromes including Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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