Thermo Fisher Scientific Canakinumab Recombinant Human Monoclonal Antibody

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

• Endotoxin level < 0.01 EU/µg by LAL method
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for one week.
• Store at -20 to -80°C for twelve months from the date of receipt.

Target Information

Canakinumab is a recombinant, human anti-human IL-1β monoclonal antibody of the IgG1/kappa isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and consists of two 447–448 residue heavy chains and two 214 residue light chains, with a molecular mass of approximately 145–157 kDa (deglycosylated).
Both heavy chains contain oligosaccharide chains linked at Asn298. Canakinumab binds to human IL-1β and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors. It does not bind IL-1α or IL-1 receptor antagonist (IL-1ra).

Canakinumab is marketed under the brand name Ilaris and is indicated for:

• Familial Cold Autoinflammatory Syndrome (FCAS)
• Muckle-Wells Syndrome (MWS)
• Systemic Juvenile Idiopathic Arthritis (SJIA)

Clinical trials have shown that administration every two weeks is safe and effective, providing an advantage over daily anakinra injections.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.