Thermo Fisher Scientific TSC22D4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

4-8 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the N-terminal of human TSC22D4 (aa 2-51). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TSC22D4,uniProtId:Q9Y3Q8-1,ncbiNodeId:9606,antigenRange:2-51,antigenLength:395,antigenImageFileName:PA5-40333_TSC22D4_Q9Y3Q8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-40333_TSC22D4_Q9Y3Q8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2576380

Product Specific Information

Peptide sequence: SGGKKKSSFQ ITSVTTDYEG PGSPGASDPP TPQPPTGPPP RLPNGEPSPD

Sequence homology: Dog: 90%; Guinea Pig: 93%; Human: 100%; Rat: 77%

Target Information

TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is TSC22D1.
Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.