Thermo Fisher Scientific RGS4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP SSCGAEKQKG AKSSADCASL
• Sequence homology:
  Cow: 86%
  Dog: 92%
  Guinea Pig: 93%
  Horse: 93%
  Human: 100%
  Mouse: 100%
  Rabbit: 86%
  Rat: 100%
  Sheep: 86%

Target Information

Regulator of G protein signaling (RGS) family members act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins deactivate G protein subunits of Gi alpha, Go alpha, and Gq alpha subtypes, driving them into their inactive GDP-bound forms.
Regulator of G protein signaling 4 (RGS4) belongs to this family and shares a conserved 120-amino acid RGS domain. RGS4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. It negatively regulates signaling upstream or at the level of heterotrimeric G proteins and is localized in the cytoplasm.
Alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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