Thermo Fisher Scientific CD304 (Neuropilin-1) Monoclonal Antibody (3DS304M), APC, eBioscience
마우스 CD304(Neuropilin-1)을 인식하는 단클론 항체로, APC 형광체가 결합된 제품입니다. Flow cytometry에 최적화되어 있으며, Treg, NKT, DC 등 다양한 세포 표면 단백질 분석에 활용됩니다. 4°C 보관, 동결 금지.
- 카탈로그번호
- 17-3041-8x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD304 (Neuropilin-1) Monoclonal Antibody (3DS304M), APC, eBioscience
Thermo Fisher Scientific CD304 (Neuropilin-1) Monoclonal Antibody (3DS304M), APC, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.25 µg/test
View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3DS304M |
| Conjugate | APC |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573195 |
Additional Formats
- eFluor 450
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 780
- Request custom conjugation
Product Specific Information
The monoclonal antibody 3DS304M recognizes mouse CD304 (Neuropilin-1), a type 1 transmembrane glycoprotein expressed on multiple cell types including regulatory T cells (Treg), NKT cells, dendritic cells, stem cells, neurons, endothelial cells, and neoplastic cells.
Neuropilin-1 acts as a co-receptor for type 3 semaphorins in growing neurons and contributes to angiogenesis as part of a VEGF receptor complex in endothelial cells. In mice, Neuropilin-1 is expressed on thymus-derived natural Treg but not on peripherally induced Treg.
Transient expression on recently activated non-regulatory T cells has been observed. Neuropilin-1 serves as a marker for recent thymic emigrants in mouse iNKT cells. It forms a complex with TGF-beta receptors, activating latent TGF-beta and enhancing Smad2/3 signaling.
This antibody recognizes formaldehyde-fixed and methanol-treated epitopes.
Applications Reported: Flow cytometric analysis
Applications Tested: Flow cytometric analysis of mouse splenocytes at ≤ 0.25 µg/test (100 µL final volume). Recommended careful titration for optimal assay performance.
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
Neuropilin-1 is a 923 amino acid membrane-bound coreceptor belonging to the neuropilin family. It contains two CUB domains, two F5/8 type C domains, and a MAM domain. Neuropilin-1 forms a heterodimer with Neuropilin-2 (NRP2) and binds to plexin (PLXNB1) to form semaphorin receptors.
It is primarily expressed in the nervous system and plays roles in cardiovascular development, angiogenesis, axon guidance, neuronal circuit formation, cell survival, and migration. Neuropilin-1 also functions as a receptor for semaphorins and VEGF, regulating VEGF-induced angiogenesis.
It may be implicated in advanced prostate carcinoma and breast cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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