Thermo Fisher Scientific CD279 (PD-1) Monoclonal Antibody (eBioJ105 (J105)), APC, eBioscience
Human 및 Rhesus monkey에 반응하는 PD-1 (CD279) 단일클론 항체로, APC 형광표지되어 Flow Cytometry에 적합합니다. 활성화된 T/B 세포의 PD-1 발현 분석에 사용되며, 높은 특이성과 재현성을 제공합니다. 4°C에서 암소 보관, 동결 금지.
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Applications and Tested Dilution
- Flow Cytometry (Flow): 5 µL (1 µg)/test
- Publications: View 18 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rhesus monkey |
| Published Species | Human, Mouse, Non-human primate, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioJ105 (J105) |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10598512 |
Available Formats
- Unconjugated
- APC-eFluor 780
- Biotin
- Brilliant UV 615 / 661 / 737 / 805
- Brilliant Violet 421 / 480 / 650 / 711 / 786
- PE / PE-Cyanine5 / PE-Cyanine7 / PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436 / 600 / 645 / 702 / 780
- Request custom conjugation
Product Specific Information
The J105 monoclonal antibody reacts with human PD-1 (programmed death-1), a 55 kDa member of the CD28 immunoglobulin superfamily. PD-1 contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. It is expressed predominantly on activated T and B lymphocytes.
PD-1 ligands include PD-L1 (B7-H1) and PD-L2 (B7-DC), which have overlapping functions and are expressed on normal tissues and activated antigen-presenting cells.
Costaining experiments suggest that eBioJ105 recognizes a different epitope than MIH4 (Product # 11-9969).
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and tested for flow cytometry using stimulated normal human peripheral blood cells
- Recommended Use: 5 µL (1 µg) per test in a final volume of 100 µL
- Excitation: 633–647 nm
- Emission: 660 nm
- Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
T-cell activation is regulated by inhibitory receptors such as PD-1 (PDCD-1), which bind to ligands PDL-1 and PDL-2 on antigen-presenting cells. Binding of PD-1 to its ligands inhibits immune activation in the absence of danger signals. PD-1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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