Thermo Fisher Scientific CD33 Monoclonal Antibody (OTI2C1), TrueMAB
인간 CD33 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot, IHC, Flow cytometry에 사용 가능. 1 mg/mL 농도의 액상 형태이며, PBS/BSA/glycerol 완충액에 보관. 골수계 세포 표지 및 AML 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:2,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C1 |
| Immunogen | Full-length human recombinant CD33 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules capable of recruiting protein tyrosine phosphatases SHP-1 and SHP-2. These motifs also mediate ubiquitin-dependent removal of the receptor from the cell surface.
CD33 is expressed on cells of the myelomonocytic lineage and binds sialic acid residues in N- and O-glycans on cell surfaces. It serves as a therapeutic target for acute myeloid leukemia (AML). The protein is found on granulocyte and macrophage precursors in bone marrow, but not on pluripotent stem cells. It is also expressed on peripheral monocytes and is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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