Thermo Fisher Scientific NPC1 Monoclonal Antibody (17B5)
NPC1 단백질을 인식하는 Mouse monoclonal antibody(클론 17B5)로 Western blot, ICC/IF, ELISA에 적합. Human 시료 반응성. Protein A로 정제된 액상 형태이며, 0.5 mg/mL 농도. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 3 publications |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| ELISA | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 17B5 |
| Immunogen | Fragments of Human NPC1 conjugated to a carrier protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533196 |
Target Information
Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by abnormal lipid sequestration, including cholesterol and glycosphingolipids.
The NPC1 protein is a large membrane protein located in endosomes and lysosomes, mediating intracellular cholesterol trafficking through binding to its N-terminal domain.
NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol.
Additionally, NPC1 has been identified, along with FTO, MC4R, and PTER, as a new risk locus for early-onset and morbid adult obesity in European populations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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