Thermo Fisher Scientific GALE Polyclonal Antibody
Rabbit polyclonal antibody targeting human GALE protein. Validated for ICC/IF applications with high specificity. Supplied as a liquid, unconjugated form at 0.2 mg/mL. Suitable for research use only, not for diagnostic procedures.
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- PA5144982
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence, range 58–182. Recombinant protein control fragment (Product # RP-109862) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091802 |
Product Specific Information
Immunogen sequence:
RSVEFEEMDI LDQGALQRLF KKYSFMAVIH FAGLKAVGES VQKPLDYYRV NLTGTIQLLE IMKAHGVKNL VFSSSATVYG NPQYLPLDEA HPTGGCTNPY GKSKFFIEEM IRDLCQADKT WNAVL
Antigen sequence identity:
Mouse 94%; Rat 91%
Target Information
This gene encodes UDP-galactose-4-epimerase, an enzyme catalyzing two analogous reactions:
- Epimerization of UDP-glucose to UDP-galactose
- Epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine
The enzyme’s bifunctional nature means mutant cells or individuals rely on exogenous galactose and N-acetylgalactosamine for glycoprotein and glycolipid synthesis.
Mutations in this gene cause epimerase-deficiency galactosemia (galactosemia type 3), characterized by liver damage, early-onset cataracts, deafness, and mental retardation, with severity ranging from mild (peripheral form) to severe (generalized form).
Multiple alternatively spliced transcripts encoding the same protein have been identified.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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