Thermo Fisher Scientific GALE Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:

RSVEFEEMDI LDQGALQRLF KKYSFMAVIH FAGLKAVGES VQKPLDYYRV NLTGTIQLLE IMKAHGVKNL VFSSSATVYG NPQYLPLDEA HPTGGCTNPY GKSKFFIEEM IRDLCQADKT WNAVL

Antigen sequence identity:
Mouse 94%; Rat 91%

Target Information

This gene encodes UDP-galactose-4-epimerase, an enzyme catalyzing two analogous reactions:

• Epimerization of UDP-glucose to UDP-galactose
• Epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine

The enzyme’s bifunctional nature means mutant cells or individuals rely on exogenous galactose and N-acetylgalactosamine for glycoprotein and glycolipid synthesis.
Mutations in this gene cause epimerase-deficiency galactosemia (galactosemia type 3), characterized by liver damage, early-onset cataracts, deafness, and mental retardation, with severity ranging from mild (peripheral form) to severe (generalized form).
Multiple alternatively spliced transcripts encoding the same protein have been identified.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.