Thermo Fisher Scientific MFN1 Monoclonal Antibody (OTI4D11), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism. These proteins may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes that regulate mitochondrial fusion and are essential for embryonic development.
When ectopically expressed, MFN1 inhibits the apoptosis-associated conformational change in the apoptotic protein Bax (but not its mitochondrial translocation), suggesting a regulatory role in Bax activation on the outer mitochondrial membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.