Thermo Fisher Scientific MFN1 Monoclonal Antibody (OTI4D11), TrueMAB
MFN1 단백질을 인식하는 Mouse monoclonal antibody로 Western blot과 IHC(P)에서 검증됨. 인간 유래 단백질(aa 209-469)을 면역원으로 사용. 동결건조 형태, PBS buffer(8% trehalose)로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 209–469 of human MFN1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism. These proteins may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes that regulate mitochondrial fusion and are essential for embryonic development.
When ectopically expressed, MFN1 inhibits the apoptosis-associated conformational change in the apoptotic protein Bax (but not its mitochondrial translocation), suggesting a regulatory role in Bax activation on the outer mitochondrial membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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