Thermo Fisher Scientific IkB alpha Monoclonal Antibody (6A920)
IkB alpha 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, WB, IHC, ICC, Flow, IP 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Protein G 정제, 1 mg/mL 농도, PBS 내 0.02% sodium azide 함유. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
| Flow Cytometry (Flow) | 0.25–1 µg per million cells | - |
| Immunoprecipitation (IP) | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6A920 |
| Immunogen | Recombinant protein corresponding to amino acid residues 32–291 of human IkBα |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at –20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537671 |
Product Specific Information
Suggested positive control: Daudi, Jurkat, or NIH-3T3 cells.
Target Information
IkB-alpha is a 40 kDa protein that functions to inhibit NF-kappaB activity through protein-protein interactions with NF-kappaB dimers in the cytosol. This interaction masks the nuclear localization sequence of NF-kappaB, preventing its translocation to the nucleus. Various stimuli, including TNF-alpha, IL-1 beta, chemokines, PMA, growth factors, LPS, UV irradiation, viral infection, and other stresses, can activate NF-kappaB by inducing degradation of IkB-alpha.
In humans, the IkB-alpha gene is located on chromosome 14q. Activation of NF-kappaB requires phosphorylation of IkB on specific serine residues (Ser32 and Ser36), leading to its degradation. IkB kinase alpha (IKKα) interacts with and phosphorylates IkB-alpha at these sites. IKKα, in complex with IKKβ and IKKγ, is essential for NF-kappaB activation in response to proinflammatory cytokines, regulated by NF-kappaB inducing kinase (NIK).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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