Thermo Fisher Scientific Phospho-TOP2A (Ser1213) Polyclonal Antibody
인산화된 Ser1213 부위의 TOP2A 단백질을 특이적으로 인식하는 Rabbit Polyclonal 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, 인간과 생쥐 시료에서 반응합니다. 고순도 정제 및 안정적인 PBS/glycerol buffer로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TOP2A (Accession P11388), corresponding to amino acid residues around phosphorylated Ser1213 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817227 |
Product Specific Information
Antibody detects endogenous levels of TOP2A only when phosphorylated at Ser1213.
Target Information
Topo II alpha plays important roles in DNA synthesis and transcription, as well as chromosomal segregation during mitosis.
It is a sensitive and specific marker of late S-, G2-, and M-phases in transformed and developmentally regulated normal cells.
Topo II alpha is also implicated in drug resistance of tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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