Thermo Fisher Scientific Caspase 8 Polyclonal Antibody
Caspase-8 단백질 검출용 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합하며 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, 세포 사멸 연구에 활용 가능.
- 카탈로그번호
- PA520118
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Caspase 8 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | View 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 2–20 µg/mL | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 16 amino acid synthetic peptide from near the C-terminus of human Caspase-8 isoform A (within the last 50 amino acids). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153608 |
Product Specific Information
- Reacts with human Caspase-8 isoform A.
- Suggested positive controls: Jurkat cell lysate, human spleen, mouse spleen, rat spleen tissue lysate.
- Compatible blocking peptide: PEP-0236.
- Depending on sample type, full-length or cleavage products may be observed.
Target Information
Caspase 8 (CASP8) is a cysteine-aspartic protease involved in apoptosis execution. It exists as an inactive proenzyme that becomes active through proteolytic processing, forming large and small subunits. Caspase 8 interacts with FADD via its death effector domain, playing a key role in Fas-mediated apoptosis and other apoptotic pathways. It has been implicated in neurodegenerative diseases such as Huntington’s disease. Overexpression induces apoptosis, which can be inhibited by ICE family-specific inhibitors. Multiple alternatively spliced isoforms exist.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.