Thermo Fisher Scientific MCL-1 Polyclonal Antibody
MCL-1 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응합니다. Western blot, ICC/IF, ELISA에 사용 가능하며, 1 mg/mL 농도의 액상 형태입니다. PBS 버퍼에 0.02% sodium azide 포함, 냉장 보관 권장. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
| ELISA | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to 16 amino acids near the amino-terminus of human Mcl-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152825 |
Product Specific Information
- A suggested positive control is Raji cell lysate.
- PA5-20121 can be used with blocking peptide PEP-0239.
Target Information
MCL1 (Myeloid cell leukemia-1) belongs to the Bcl-2 family and is involved in cell differentiation and maintenance of viability, but not proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. The carboxy terminal of MCL1 and Bcl-2 share significant sequence homology. Expression of MCL1 increases upon exposure to DNA damaging agents such as ionizing radiation, ultraviolet radiation, and alkylating drugs.
Enhanced expression of MCL1 is associated with mitochondria and complements Bcl-2 expression in differentiating ML-1 cells. MCL1 promotes cell viability under apoptotic conditions, potentially by neutralizing pro-apoptotic proteins like Bim or Bak. It is expressed in multiple cell types and is essential for embryogenesis and lymphocyte development. MCL1 exists as two isoforms, MCL1L and MCL1S; overexpression of MCL1S promotes cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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