Thermo Fisher Scientific CD43 Monoclonal Antibody (MEM-59), PE

Thermo Fisher Scientific CD43 Monoclonal Antibody (MEM-59), PE

Applications

• Flow Cytometry (Flow)

Tested Dilution: 20 µL/1x10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Alexa Fluor 700
• Biotin
• FITC
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes a neuraminidase-sensitive extracellular epitope on CD43 (Leukosialin), a 95–135 kDa type I transmembrane glycoprotein (mucin-type) involved in lymphocyte activation. CD43 is expressed by platelets and at high levels on all leukocytes; it is negative on resting B lymphocytes and erythrocytes.

Target Information

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on most hematopoietic cells. It contributes to a repulsive barrier interfering with cellular adhesion, but can also promote leukocyte aggregation. Through interaction with actin-binding proteins ezrin and moesin, CD43 regulates T-cell morphology and cell-cell interactions during lymphocyte traffic. CD43 signaling enhances LFA-1 adhesiveness while counteracting LFA-1 induction via other receptors. Expression of CD43 induces tumor suppressor p53, but in p53/ARF deficiency promotes tumor proliferation and viability. CD43 is an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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