Thermo Fisher Scientific Ataxin 3 Polyclonal Antibody
Rabbit polyclonal antibody specific to human Ataxin 3. Validated for WB, IHC (P), and Flow Cytometry. Recognizes epitope within amino acids 261–288 of ATXN3. Suitable for research on Machado-Joseph disease mechanisms. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 261–288 of human ATXN3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543751 |
Target Information
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder caused by expansion of (CAG)n repeats in the coding region of the Ataxin-3 (ATXN3) gene. The MJD protein interacts with transcription regulators such as CBP, p300, and PCAF, repressing transcriptional activity. It functions as a histone-binding and deubiquitinating enzyme. The number of CAG repeats inversely correlates with age of onset.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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