Thermo Fisher Scientific CD49d (Integrin alpha 4) Chimeric Recombinant Rabbit Monoclonal Antibody (21.6)
인간 CD49d(Integrin alpha 4)에 특이적인 키메라 재조합 토끼 단일클론 항체. ICC/IF, ELISA, Inhibition Assay에 사용 가능. HEK293 세포에서 발현된 IgG kappa 형식의 비결합형 항체. 단백질 A 정제, 1 mg/mL 농도, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | Assay-dependent |
| Inhibition Assays | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 21.6 |
| Immunogen | Alpha-4 integrin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074472 |
Product Specific Information
Specificity: This antibody binds to human alpha-4-integrin.
Target Information
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chain. The alpha4 chain associates with either beta1 or beta7 chain. The ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 are located on the alpha4 chain. These ligands include MadCAM, VCAM, and fibronectin. MadCAM is known as the principal ligand for integrin alpha4beta7. It has also been demonstrated that the HIV-1 envelope can mimic MadCAM by binding to and signaling through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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