Thermo Fisher Scientific AFP Monoclonal Antibody (P5B8)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-14666 can be used for immunofluorescence analysis of AFP in the endoderm derived from human embryonic stem cells.
By Western blot, MA5-14666 detects endogenous AFP protein in early hepatocyte-like cells derived from human embryonic stem cells.

Product MA514666 is a smaller package size of MIA1305 (formerly sold as a Seradyn product).

Target Information

AFP (Alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract, and liver during fetal life.
AFP expression in adults is often associated with hepatoma or teratoma, though hereditary persistence of AFP may occur without pathology.
AFP is considered the fetal counterpart of serum albumin, with both genes located in tandem on chromosome 4.
AFP exists in monomeric, dimeric, and trimeric forms and can bind copper ions, nickel ions, fatty acids, and bilirubin.

Serum AFP levels are used in prenatal screening for neural tube defects and can be elevated in hepatocellular carcinoma, teratoblastoma, colorectal cancer, pancreatic cancer, and germ cell neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.