Thermo Fisher Scientific Amyloid beta Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive control: Human Brain (Alzheimer)
• Cellular location: Membrane

Target Information

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP by beta-secretase (BACE), an aspartyl protease synthesized as a propeptide and activated by furin. The mature BACE cleaves beta APP, producing a membrane-bound remnant that is further processed by gamma-secretase. Gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, cleaves within the transmembrane domain to generate the amyloid beta peptide. Nicastrin, a transmembrane glycoprotein associated with presenilins, binds to the carboxyl-terminus of beta APP and modulates Abeta production. Abeta is a filamentous extracellular protein found in amyloid cores, neuritic plaques, and neurofibrillary tangles. Alzheimer’s disease, characterized by abnormal protein deposits, is the most common cause of senile dementia. Beta amyloid deposits are also found in Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.