Thermo Fisher Scientific Human MKNK1 (MNK1), GST Tag Recombinant Protein

Thermo Fisher Scientific Human MKNK1 (MNK1), GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution: Assay-dependent
Publications: [References not provided]

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use original packaging until exhausted.
• For larger sizes, aliquoting may reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
• Never store kinase diluted.
• Properly stored at -80°C, guaranteed for 6 months from date of purchase.
• Protein Form: Recombinant, Full Length

Target Information

The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases and regulate protein synthesis by phosphorylating eIF4E on Ser209, potentially contributing to tumorigenesis.
Overexpression of Mnk2 increases phosphorylation of endogenous eIF-4E, indicating its role as an eIF-4E kinase in vivo.
Mnk2 may participate in cellular responses to environmental stress and cytokines.
Expression of active mutants of MNK1 and MNK2 in 293 cells reduces cap-dependent translation relative to cap-independent translation.
Human Mnk2 is homologous to murine Mnk2 (≈94% identical) and human Mnk1 (71% identical).
In vitro phosphorylation studies show Mnk2 is a better substrate than Mnk1 for Erk2, p38MAPKα, and p38MAPKβ.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.