Thermo Fisher Scientific Human DNA-PK Native Protein

Thermo Fisher Scientific Human DNA-PK Native Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

For maximum recovery, please spin prior to use. Aliquots of the 5 µg, 10 µg, and 20 µg sizes are not recommended; materials can be used directly from the original packaging until exhausted. For larger sizes, aliquoting can reduce freeze/thaw cycles, but aliquots below 20 µL are not recommended. Do not store kinase diluted. If properly stored at -80°C, this product is guaranteed for 6 months from date of purchase.

Native human protein purified from MOLT-4 cells. No special measures were taken to activate this kinase.

Protein Form: Full Length

Target Information

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase closely related to PI3 kinases and can be inhibited by small molecules targeting PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex required for expression of most genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting pre-initiation complex formation. Multiple transcript variants encoding different isoforms have been identified for DNA-PK.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.