Thermo Fisher Scientific RUSC1 Polyclonal Antibody
Thermo Fisher Scientific의 RUSC1 Polyclonal Antibody는 인간 RUSC1 단백질에 특이적으로 반응하는 rabbit IgG 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RUSC1. Recombinant protein control fragment (Product #RP-94357). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646882 |
Product Specific Information
Immunogen sequence:
RRPSSWLPPT VSVLALVKRG APPEMPSPQE LEASAPRMVQ THRAVRALCD HTAARPDQLS FRRGEVLRVI TTVDEDWLRC G
Sequence identity:
- Mouse: 79%
- Rat: 80%
Target Information
RUSC1 (also known as NESCA) shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper, and SH3 domains, with over 30% amino acid identity.
RUSC1 acts as an adapter protein that binds to the TrkA receptor and is necessary for NGF-induced neurite growth of PC12 cells. It interacts with IKK-gamma, the regulatory subunit of the IKK complex required for NF-kappa-B activation in signaling pathways such as TNF-R or TLR.
RUSC1 also binds to the E3 ubiquitin ligase TRAF6, catalyzing RUSC1 polyubiquitination. Overexpression of RUSC1 inhibits TRAF6-mediated polyubiquitination of IKK-gamma, suggesting RUSC1 as a link in the IKK-gamma-mediated NF-kappa-B activation pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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