Thermo Fisher Scientific HDAC3 Monoclonal Antibody (3G6)
HDAC3 단백질을 인식하는 Thermo Fisher의 mouse monoclonal 항체로, Western blot, ICC/IF, IP에 사용 가능. Human 및 Mouse 반응성. Protein G 정제, 1 mg/mL 농도, PBS buffer에 0.1% sodium azide 포함. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:400–1:800 | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G6 |
| Immunogen | Human C-terminal peptide (identical in mouse). Sequence: aa 411–428 (NEFYDGDHDNDKESDVEI) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539452 |
Product Specific Information
Western blot detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.
It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1.
This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis.
This gene is regarded as a potential tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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